We study how the gut microbiota communicate with the enteric immune and nervous systems, to control inflammation and tolerance, in health and disease (including IBD, autoimmunity, cancer and more). Our experimental approach combines a unique gut organ culture system (Yissachar et al., Cell, 2017) with next-generation sequencing and state-of-the-art molecular, cellular and immunological methodologies.
We are looking for an energetic, curious, team-player and quick learning postdoctoral fellow. Experience in immunology, neuroimmunology and bioinformatics is advantageous.
Interested candidates with background in experimental or computational biology are welcome to send their CV.
Duscha A*, Gisevius B*, Hirschberg S*, Yissachar N*, Stangl GI, Eilers E, Bader V, Haase S, Kaisler J, David C, Schneider R, Troisi R, Zent D, Hegelmaier T, Dokalis N, Gerstein S, Del Mare-Roumani S, Amidror S, Staszewski O, Poschmann G, Stühler K, Hirche F, Balogh A, Kempa S, Holm JB, Massa MG, Nielsen HB, Faissner A, Lukas C, Gatermann SG, Scholz M, Przuntek H, Prinz M, Forslund SK, Winklhofer KF, Müller DN, Linker RA, Gold R, and Haghikia A. Propionic acid shapes the course of multiple sclerosis by a distinct immunomodulatory mechanism. Cell. 180(6):1067-1080. * Denotes equal contribution.
Yissachar N. Ménage à trois: regulation of host immunity by enteric neuro-immune-microbiota cross talks. Current Opinion in Neurobiology. 62:26-33. (2019)
Yissachar N, Zhou Y, Ung L, Lai NY, Mohan JF, Ehrlicher A, Weitz DA, Kasper DL, Chiu IM, Mathis D and Benoist C. An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk. Cell. 168:1135-1148 (2017)
This work was highlighted by Ivanov, Trends in Immunology (2017)
This work was highlighted by Thomas, Nature Reviews Gastro and Hepato. (2017)
This work was recommended in F1000 Prime (2017)
Yissachar N*, Sharar-Fischler T*, Cohen AA, Reich-Zeliger S, Russ D, Shifrut E, Porat Z and Friedman N. Dynamic response diversity of NFAT isoforms in individual living cells. Molecular Cell. 49:322-30 (2013) * Denotes equal contribution
This work was highlighted by Kalo and Shav-Tal, Genome Biology 14:102 (2013)