Aging is the primary risk factor for many human pathologies, including cardiovascular and neurodegenerative diseases, cancer, and diabetes. Yet, understanding how and why we age remains one of the biggest challenges in biology. To address a major challenge in aging research, the lack of a short-lived vertebrate model, we have developed the first genetic platform for rapid exploration of aging and disease in the African turquoise killifish; the shortest-lived vertebrate model with a lifespan of 4-6 months (Harel et al, Cell 2015).
Have a look at the fantastic video abstract of the lab and our research.
This genome-to-phenotype platform includes a sequenced genome, CRISPR/Cas9-based genome editing, and mutant fish for many aging- and disease-relates genes.
Using state-of-the-art genome engineering, in-vivo imaging, single-cell, and computational approaches, the Harel lab is exploring fundamental questions in aging biology, such as why is aging such a strong driver of disease? And what is the molecular basis behind the outstanding diversity of vertebrate lifespan (which can reach up to 1000-fold differences between vertebrates).
Located @ the beautiful Giv’at Ram campus (HUJI), we are looking for highly motivated graduate students and postdocs interested in cutting-edge aging research. Have a look at our outstanding lab members, and recent activities.
Required elements for research-based postdoc applications
We are looking for highly motivated graduate students and postdocs, with either and experimental of computational training. If you are interested in joining the lab, please send an email to Itamar (firstname.lastname@example.org). Please include your CV with references and a brief statement of why you are interested in our work.
Phone: +972-(0)2-6585918 (Office, Rm 3-536)
Address: Silberman Institute of Life Sciences
The Hebrew University of Jerusalem, Givat Ram,
We look forward to hearing from you!