For Osip Schwartz, uncovering how biological systems work is both rewarding and ethical. Yet the clarity of physics also fascinates him. As a result, his scientific experiments in microscopy both advance physics and bring about better tools for life science imaging. For his PhD in Physics at Weizmann Institute of Science, he built a novel optical microscope, the first in the world to improve imaging resolution by incorporating quantum statistics characteristic of light.
Dr. Schwartz opened his lab in the Department of Physics of Complex Systems at the Weizmann Institute of Science where he is working to introduce laser beams into a transmission electron microscope. His research group studies quantum interactions of light and free-space electrons. He hopes to use laser control of electron waves to improve electron microscopes by providing increased contrast, better penetration capabilities in thicker samples, and rapid three-dimensional imaging.
Dr. Schwartz also continues to address the problem of radiation damage in samples, a problem he first addressed during his postdoc at UC Berkeley. There, he worked on phase plates, which were originally invented for light microscopy, enabling imaging of previously invisible transparent cells. A different type of phase plate was needed for electron microscopy, since placing material objects in the electron beam often caused them to charge up and disintegrate. Dr. Schwartz’ phase plate consisted of a focused laser beam with the highest continuous‑wave laser intensity ever achieved. A patent has been filed for it, and it is being developed as a practical imaging tool.
Dr. Schwartz’s work has been recognized with the Human Frontier Scientific Program Postdoctoral Fellowship, given annually to 10 non-biologists worldwide whose research has an impact on biological sciences; the Adams Fellowship of the Israel Academy of Sciences and Humanities, given annually to 10 scientists in all of Israel; and with the Budker Fellowship from the Budker Institute for Nuclear Physics in Novosibirsk, Russia, his birthplace.