Moran Shalev-Benami, Zuckerman Faculty Scholar, publishes paper in Biomedicines
Weizmann Institute of Science
Assessment of structure–activity relationships for anti-protozoan activity revealed a strategy for preparing potent anisomycin derivatives with reduced host toxicity. Thirteen anisomycin analogs were synthesized by modifying the alcohol, amine, and aromatic functional groups. An entry point for differentiating activity against Leishmania versus host has been uncovered by this systematic study.